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Molecular Biopharmaceutics

Online Shop | Pharmaceutical Press | Professional Pharmaceutical Books | Molecular Biopharmaceutics

Molecular Biopharmaceutics
Aspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation

£128.25 RRP: £135.00 You save £6.75 (5.0%)

ISBN: 9780853697220
Publisher: Pharmaceutical Press
Date Published: Nov 2009
Format: Hardback

Covers a complex and developing academic scientific area, comprehensively encapsulating the essentials of the topic. The book's focus is on describing the interplay between the chemistry of drug molecules and membrane transporters.

It also aims to guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.
Starting with an introduction to the topic, Molecular Biopharmaceutics then considers the following:
•physico-chemical characterization of drug candidates
•membrane transport of drug candidates
•describing and predicting bioavailability

This topic is of increasing importance in drug development. This book will be an invaluable resource for postgraduate pharmaceutical science students, biopharmaceutical scholars, scientist within academia and pharmaceutical scientists.

Contents:
Part 1 Introduction to Molecular Biopharmaceutics

Part 2 Drug Characterization and Preformulation
1. Pka, Solubility, Liphophilicity and Solid State Characterization of Drug Candidates
2. Stability of Drug Candidates in Aqueous Solutions
3. Kinetics of Acid, Base and Enzyme Catalyzed Hydrolysis
4. Chemical Approaches to Improve Drug Delivery and Formulation of Drug Candidates
5. Preformulation:

Part 3 Drug Delivery Across Biological Membranes
6. Biological Membrane Structures
7. Diffusional Permeation of Drug Candidates
8. Carrier Mediated Transport Kinetics
9. Classification of Human Membrane Transporters
10. Absorptive Transporters
11. Efflux Transporters
12. Preclinical Evaluation of Drug Transport

Part 4 Dosage Form Evaluation
13. In Vitro Drug Dissolution
14. Biopharmaceutical Classification System
15. Biosimulation Studies

Part 5 Conclusions and Future Perspectives

Download Sample Chapter

Online Shop | Pharmaceutical Press | Professional Pharmaceutical Books | Molecular Biopharmaceutics

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